pharmacological properties of some 3-substituted indole derivatives, a concise overview

Authors

kobra nikoofar

diba kadivar

samaneh shirzadnia

abstract

indole is a nitrogen-containing heterocycle. it is a very important motif in agriculture and pharmacy. many compounds containing indole moiety has been isolated form nature. it is also an important part in natural alkaloids. tryptophan is an amino acid which posses indole. 3-sustituted indoles are the main group of its derivatives. because the wide-spread application of 3-substituted indolic compounds their synthetic procedures are in demand by organic chemists. in this review we have focused on about twenty compound of 3-substituted indole derivatives that showed pharmacological properties. a concise synthetic route for some of them has also been reported. the main pharmaceutical properties of these compounds are antibacterial, anticancer and antimicrobial activities.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Pharmacological properties of some 3-substituted indole derivatives, a concise overview

Indole is a nitrogen-containing heterocycle. It is a very important motif in agriculture and pharmacy. Many compounds containing indole moiety has been isolated form nature. It is also an important part in natural alkaloids. Tryptophan is an amino acid which posses indole. 3-Sustituted indoles are the main group of its derivatives. Because the wide-spread application of 3-substituted indolic co...

full text

Pharmacological evaluation of some new 2-substituted pyridine derivatives.

In the present study, a series of 2-substituted-pyridines were synthesized and characterized by IR, (1)H-NMR and Elemental Analysis. The compounds were assayed against seizures induced by maximal electro shock (MES) and pentylenetetrazole (scMet). Neurologic deficit was evaluated by the rotarod test. The decrease in the elevated motor activity by introceptive chemical stimuli (amphetamine antag...

full text

Antifungal activities of some indole derivatives.

Nine indole derivatives were evaluated in vitro against Fusarium graminearum, Alternaria alternata, Helminthosporium sorokinianum, Pyricularia oryzae, Fusarium oxysporum f. sp. vasinfectum, Fusarium oxysporum f. sp. cucumarinum, and Alternaria brassicae. Most of the compounds were found to possess antifungal activities. Especially compounds 2, 5, 8, and 9 exhibited broad-spectrum antifungal act...

full text

some properties of fuzzy hilbert spaces and norm of operators

in this thesis, at first we investigate the bounded inverse theorem on fuzzy normed linear spaces and study the set of all compact operators on these spaces. then we introduce the notions of fuzzy boundedness and investigate a new norm operators and the relationship between continuity and boundedness. and, we show that the space of all fuzzy bounded operators is complete. finally, we define...

15 صفحه اول

Highly diastereoselective samarium diiodide induced cyclizations of new 3-substituted indole derivatives.

Herein, we describe the synthesis of new functionalized tricyclic and tetracyclic indole derivatives via samarium diiodide induced ketyl cyclizations. The intermediate samarium organyls were either protonated using different proton sources or alkylated with various electrophiles in a highly diastereoselective manner. The obtained products were subjected to further transformations leading to syn...

full text

Synthesis of N-substituted aminoalkyl derivatives of some epoxyisoindoles as potential pharmacological agents.

Grogan and Rice reported a number of imides of epoxyisoindole sort. Some pharmacological testing was performed which revealed their bioactivity. Except of their work, only scattered examples of derivatives with oxygen-bridged ring have appeared in the literature; this approach has also been used by us in the synthesis of some new potential drugs. This paper reports the synthesis of a number of ...

full text

My Resources

Save resource for easier access later


Journal title:
iranian chemical communication

Publisher: payame noor university (pnu)

ISSN 2423-4958

volume 2

issue Issue 4 (pp. 236-325) 2014

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023